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The GP1 subcomponent of the New World arenavirus GP is a primary target of the neutralizing antibody response, which has been shown to be effective in the prevention and treatment of infection. Here, we characterize the structural basis of the antibody-mediated immune response that arises from immunization of mice against Junín virus and Machupo virus, two rodent-borne zoonotic New World arenaviruses.

Original publication

DOI

10.1128/mbio.02650-21

Type

Journal article

Journal

mBio

Publisher

American Society for Microbiology

Publication Date

22/03/2022