Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccines.
Bahar MW. et al, (2021), NPJ Vaccines, 6
Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein.
Rissanen I. et al, (2020), eLife, 9
Low-dose phase retrieval of biological specimens using cryo-electron ptychography
Zhou L. et al, (2020), Nature Communications, 11
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
Watanabe Y. et al, (2020), Nature Communications, 11
Focus of our research
To understand the biology of viruses and how they infect their host cells, it is important to be able to study the viruses in their infectious native state and also in their cellular context.
Groups in OPIC focus in studying structures of purified virus particles and virus host-cell interactions. OPIC houses state-of-the-art biosafety containment laboratories at ACDP category 3 and DEFRA 4 levels of containment. This facilitates the study of a number of viruses that are important to human and animal health.
Examples of our research
STRUCTURAL CELL BIOLOGY OF VIRUS INFECTION
Kay Grünewald - Our aim is a comprehensive picture of the functional interaction between viral protein complexes and cellular structures in the course of the infection. Viruses being studied include Herpes simplex virus type 1 and HIV. Read more
STRUCTURES AND HOST CELL INTERACTIONS OF EMERGING VIRUSES
Juha Huiskonen - We study the ultrastructure and cell entry mechanisms of viruses causing heamorrhagic fevers. Current focus is members of Arenaviridae (Lassa virus) and Bunyaviridae (Rift Valley fever virus). Read more
A PIPELINE FOR STRUCTURAL VACCINOLOGY
Dave Stuart - We use atomic resolution structures of viral particles to guide the design of stabilized vaccines. This ‘structural vaccinology’ approach is used for the development of a safe, synthetic stabilised virus-like particle (VLP) based vaccine for foot and-mouth disease virus and poliovirus. Read more